With severe carotid atherosclerosis in the atherosclerosis in patients with cerebral infarction even in drug-intervention, the recurrence rate remains as high as 18.5%, in particular, has severe carotid artery stenosis in patients with cerebral infarction significantly increased the risk of recurrence, ulcers spot The patients with cerebral infarction recurrence of the danger of increased seven times.Therefore, the carotid atherosclerosis actively intervene to reduce the carotid atherosclerosis extent and degree of stenosis, the stability of carotid atherosclerosis, the prevention of the recurrence of cerebral infarction may have an important role.

Cerebral infarction, the recurrence rate of 4 per cent to 14 per cent, of which one year after the stroke of recurrence about 13 percent, after four years, the annual recurrence of 4%. Anti-platelet aggregation drug widely used in the two ischemic stroke prevention, and aspirin as the widely used anti-platelet drugs, in the role of secondary prevention has been confirmed by evidence-based medicine, aspirin therapy to soft Spots and ulcers reduce plaque, hard spots and flat spots increased, that of aspirin in a stable atherosclerotic plaque in a certain role.

On the basis of aspirin in addition to simvastatin treatment can significantly reduce the recurrence rate of cerebral infarction. Treatment of 8 to 12 weeks after the review of carotid color Doppler ultrasound, found that simvastatin treatment group with carotid atherosclerosis and mild changes in carotid atherosclerosis, mild narrow, hard spots and flat spots of cases increased, while severe Carotid atherosclerosis and severe carotid artery stenosis, soft spots and ulcers spot decreased significantly compared with treatment before there were significant differences, might be prompted to simvastatin treatment of carotid atherosclerosis and reduce the impact of recurrent cerebral infarction . Statin drugs is the strongest known role of cholesterol-lowering drugs. Many studies show that: regardless of whether patients with increased serum cholesterol and accept simvastatin treatment, stroke and transient ischemic attack decreased the incidence rate of 23% and 5%. In addition to statin drugs to lower cholesterol, there are a variety of biological activity: enhance immune suppression and anti-inflammatory effect, regulating thrombosis inhibit platelet function: to improve vascular endothelial cells in systolic and diastolic function, enhance the endothelial cells the ability to dissolve fibrin; Inhibit smooth muscle cell migration and proliferation and enhance endothelial nitric oxide synthase, and so on, thus delaying carotid atherosclerosis process, stability or dissipated atherosclerosis plaque to make it difficult to break down, to reduce artery embolization and thrombosis, Reduce the degree of carotid artery stenosis, to prevent recurrence of the role of cerebral infarction.